About the Powers & Brissova Research Group


Read about our latest discovery concerning the role of α cells in human Type 1 Diabetes via Vanderbilt News or the research paper.

Pancreatic islets are highly specialized mini-organs that regulate blood glucose by secreting insulin, glucagon, and other hormones in response to physiologic stimuli such as glucose. A deficiency or a dysfunction of the insulin-producing β cells of the islet is critical to the development of all forms of diabetes.

The Powers & Brissova group is working to understand and reverse β cell and islet abnormalities and dysfunction in diabetes. In our projects, we are studying the pathogenesis of human diabetes by conducting, translating, and integrating studies about the human pancreas and islet biology.

Our research team of scientists, postdoctoral fellows, graduate students, medical students, undergraduate students, and research assistants has interdisciplinary collaborations with vascular biologists, developmental biologists, biomedical engineers, chemists, and bioinformaticians at Vanderbilt and around the world (Seattle, Palo Alto, Pasadena, Worcester, Boston, Bar Harbor, New York, Geneva, and Gainesville). We are part of the NIH-funded Human Islet Research Network (HIRN).

The Powers & Brissova Research Group is located at Vanderbilt University Medical Center (Vanderbilt Diabetes Center, Department of Medicine, and Department of Molecular Physiology and Biophysics), in Nashville TN.



We are located in Nashville, TN, on the beautiful Vanderbilt University campus! Vanderbilt is a private research university and medical center and offers a wealth of research opportunities, resources and community!

MRB-IV Research Building


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7465 Medical Research Bldg IV
2215 Garland Avenue
Nashville, TN 37232-0475